Jennifer Houser

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  Student Presentation: Modeling Latency of Thalmocortical Fast-Spiking Interneurons in Schizophrenia
  Jennifer Houser

  Neural thalamocortical circuits relay external sensations from to the thalamus to the cortex where sensory information is then processed. Feedforward inhibition involving a subtype of fast-spiking interneurons, which are marked by the calcium-binding protein parvalbumin, reduce the chance that a postsynaptic neuron will fire an action potential. Consequences on the circuit due to the absence of parvalbumin expression in fast-spiking neurons in schizophrenia patients are caused by fast-spiking latency. In this presentation, we present a conventional neuron model. We will show how to develop a mathematical model to incorporate a latency effect as well as show numerical simulations.